His recent work led to the development of a mass spectrometry-based hybrid method for assembly modelling of large and heterogeneous protein complexes. (2017). Richard is working on the modelling of HDX data from MD simulations. Selected publications#Co-first authorship; *Co-corresponding authorship• Martens, C. Shekhar, M., Borysik, A. J., Lau, A. M., Reading, E., Tajkhorshid, E., Booth, P. J., Politis, A. Chemistry. Argyris Politis. Department. Direct protein-lipid interactions shape the conformational landscape of secondary transporters. (2018). Dr. Argyris Politis is a Senior Lecturer at King´s College London, Department of Chemistry. Biography. I am a Research Fellow currently based at University College London in the group of Prof. David Jones, with interests in predicting protein structure and behaviour using machine learning methods. My PhD project under the supervision of Dr. Argyris Politis involves the utilisation of a novel combination of mass spectrometry (MS)-based methodologies - hydrogen/deuterium exchange-MS, … E-Mail dhfackler@ks.uiuc.edu. Ygia Polyclinic Private Hospital located in Limassol, Cyprus. (2018). A mass spectrometry-based hybrid method for structural modelling of protein complexes. Dr Argyris Politis (Principal Investigator) Argyris has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. Contact Donna Hutchcraft Fackler. Contact Donna Hutchcraft Fackler. Σήμερα πλέκουμε το εγκώμιο στους γιατρούς, τους νοσηλευτές, σε όλους τους επαγγελματίες υγείας. Argyris has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. University College London. Principal Investigator, Senior Lecturer in Systems Biology. United Kingdom . The main focus of my lab is on dissecting the molecular basis of the structure-to-function relationship of mammalian genomes. Argyris Politis. Bernadette Byrne, Argyris Politis Correspondence b.byrne@imperial.ac.uk (B.B. 8,888 were here. As a post-doctoral researcher, he has worked in Cambridge and Oxford University with Prof. Dame Carol Robinson, as well as spending time at UCSF with Prof. Andrej Sali. Structural Bioinformatician. Dr Argyris Politis Visit Website. Event Type: Seminar *** Abstract: The cell contains functional modules, which are composed of large macromolecular assemblies of proteins1. Chloe Martens, Andy M. Lau & Argyris Politis. As a post-doctoral research has worked in Cambridge and Oxford with Professor Dame Carol Robinson, as well as spending time in UCSF (Professor Andrej Sali). Institution: University of Ulster. Direct protein-lipid interactions shape the conformational landscape of secondary transporters. ISMB Seminar Series - Dr Argyris Politis - King’s College London . Latest Research Outputs. Mechanistic insight into the assembly of the HerA-NurA helices-nuclease DNA end resection complex. Valeria is an experimental post-doc exploring the application and development of HDX-MS on a variety of membrane proteins. Ruby's project involves investigating the molecular mechanism of membrane transporters and disease-related mutant variants, using a combination of native MS and HDX-MS. Co-supervised by Prof. Paula Booth (King’s College London). As a post-doctoral researcher, he has worked in Cambridge and Oxford University with Prof. Dame Carol Robinson, as well as spending time at UCSF with Prof. Andrej Sali. Dr Eamonn Reading is funded by a BBSRC Future Leader Fellowship (BB/N011201/1). King’s College London with its 200 years of heritage is recognised today as a world-leading research university, ranked 7th in the 2014 Research Excellence Framework. Dr Andy M. Lau. politis.com.cy Έχει όμως ο καιρός γυρίσματα. King's College London Welcome to the research page of Argyris Politis The aim of the Politis lab is to develop novel methods and tools to study the structural dynamics of macromolecular assemblies, important for their cellular function. Scopus Author ID: 35097785800. Richard's previous post-doc was at the National Insitute of Health in Maryland in the group of Lucy Forrest. PMID: 31605097 PMCID: PMC7058097 (available on 2020-11-01) DOI: 10.1038/s41596-019-0219-6 Abstract Biological membranes define the boundaries of cells and are composed primarily of phospholipids and membrane proteins. Dr Andy M. C. Lau 07568 578021 - andy.m.lau@outlook.com SKILLS REFERENCES Dr Argyris Politis Lecturer in Chemical Systems Biology, King’s College London, UK +44 (0)20 7848 7514 | argyris.politis@kcl.ac.uk Professor Stephen Perkins Professor of Structural Biochemistry, University College London, UK +44 (0)20 7679 7048 | s.perkins@ucl.ac.uk * (2019). King's College London . * (2019). Damon is a Waters and LIDo funded PhD student whose project focusses on the membrane protein NTSR1. Cell Chemical Biology, 25 (7): 840-8.• Ahdash, Z., Lau, A. M., Byrne, R. T., Lammens, K., Stüetzer, A., Urlaub, H., Booth, P. J., Reading, E., Hopfen, K-P., Politis, A. (2017). #Corey, R. A., #Ahdash, Z., Shah, A., Pyle, E., Allen, W. J., Lovett, J. E., Politis, A. Principal Investigator, Senior Lecturer in Systems Biology. Nature Methods, 11 (4): 402-6. This work was published in Nature Methods and Nature Chemistry. Phone 217-300-8022. The aim of the Politis lab is to develop novel methods and tools to study the structural dynamics of macromolecular assemblies, important for their cellular function. Andreas Beyer / Argyris Papantonis - C 4 Contribution of deteriorating RNA biosynthesis to cellular ageing Using transcriptome data from 5 animal species we have shown that the speed of RNA polymerase II(Pol-2) elongation increases with ageing. (2018). Understanding, describing and modulating many of the cell’s functions requires structure characterization of its macromolecular assemblies. Our group primarily focuses on membrane-resident proteins and in particular membrane transporters. I. acknowledge Prof. Paula Booth, Dr. Argyris Politis, Dr. My PhD at King’s College London in the group of Argyris Politis, developed methods of integrating data from structural mass … Dr. Argyris Politis; Pages: 17440-17445; First Published: 08 November 2018; Nicht IgG‐norieren: Die Kombination von Ionenbeweglichkeits‐Massenspektrometrie (IM‐MS) und Molekülmodellen gibt Aufschluss über die Konformationsdynamik humaner IgG‐Antikörper. DR ARGYRIS POLITIS (KINGS COLLEGE LONDON) INSIGHTS INTO THE STRUCTURE AND DYNAMICS OF TRANSIENT PROTEIN COMPLEXES FROM HYBRID MASS SPECTROMETRY The combination of mass spectrometric approaches and computational methods is being used increasingly to study protein complex structures and their dynamical interactions with their See the complete profile on LinkedIn and discover Argyris’ connections and jobs at similar companies. 06 November 2019, 1:00 pm–2:00 pm Senior Lecturer. (2018). Michael Province ... Dr. Haifa. ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery. Burton Lecture 2021. (2018). Ahdash, Z., Lau, A. M., Byrne, R. T., Lammens, K., Stüetzer, A., Urlaub, H., Booth, P. J., Reading, E., Hopfen, K-P., Politis, A. Angewandte Chemie, DOI: 10.1002/anie.201812018.• Politis, A., Stengel, F., Hall, Z., Hernández, H., Leitner, A., Waltzthoeni, T., Robinson, C. V., Aebersold, R. (2014). A mass spectrometry-based hybrid method for structural modelling of protein complexes. Contact details: E-mail: argyris.politis@kcl.ac.uk. Dr. Argyris Politis, King's College London - Dept. Argyris Politis Senior Lecturer in Chemical Systems Biology at King's College London London. of Chemistry. Welcome to the research page of Argyris Politis. Pyle, E., Kalli, A. C., Amillis, S., Hall, Z., Lau, A. M., Hanyaloglu, A. C., Diallinas, G., Byrne, B., Politis, A. Nucleic Acids Research, 45 (20): 12025-38. Valeria undertook her PhD in the Faculty of Pharmacy at the University of Copenhagen. Martens, C. Shekhar, M., Borysik, A. J., Lau, A. M., Reading, E., Tajkhorshid, E., Booth, P. J., Politis, A. Dr. Argyris Politis, King's College London - Dept. 5 Department of Chemistry, King's College London, London, UK. E-Mail dhfackler@ks.uiuc.edu. Dr. Argyris Politis, King's College London - Dept. We demonstrate that the binding of structural lipids is essential to Back to Results. Center for Biophysics and Quantitative Biology, Department of Biochemistry, NIH Center for Macromolecular Modeling … Nature Communications, 9, 4151, 9 (1).• #Corey, R. A., #Ahdash, Z., Shah, A., Pyle, E., Allen, W. J., Lovett, J. E., Politis, A. ), argyris.politis@kcl.ac.uk (A.P.) King’s College London with its 200 years of heritage is recognised today as a world-leading research Argyris has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. We will be back with more information soon. The CG data revealed two distinct CL binding sites on the SecY surface, which they were able to validate using native mass spectrometry (nMS), with Dr Argyris Politis at King’s College London, and FRET-based analysis on carefully designed variants of SecY. Structural lipids enable the formation of functional oligomers of the eukaryotic purine symporter UapA. View Argyris Politis’ profile on LinkedIn, the world’s largest professional community. *, Collinson, I. As a post-doctoral researcher, he has worked in Cambridge and Oxford University with Prof. Dame Carol Robinson, as well as spending time at UCSF with Prof. Andrej Sali. We would like to show you a description here but the site won’t allow us. Phone 217-300-8022. Phone 217-300-8022. E-Mail dhfackler@ks.uiuc.edu. Our group primarily focuses on membrane-resident proteins and in particular membrane transporters. Structural lipids enable the formation of functional oligomers of the eukaryotic purine symporter UapA. Michael Province. Her PhD project involves developing the HDX-MS technology to interrogate membrane protein dynamics and test how a native-like lipid environment affects drug binding. Our group primarily focuses on membrane-resident proteins and in particular membrane transporters. Damon will utilise a variety of cutting-edge HDX techniques to investigate NTSR1 and other membrane proteins to probe their intrinsic dynamics. The 2021 Burton Lecture will be delivered by Professor James H Naismith, FRS FRSE FMedSci. Dr. Argyris Politis; Pages: 17194-17199; First Published: 08 November 2018; Not to be IgG‐nored: An integrative strategy combining ion mobility mass spectrometry (IM‐MS) with molecular modelling can be used to study the conformational dynamics of human IgG antibodies. 10 March 2021. eLife, DOI:10.7554/eLife.41803.• Pyle, E., Kalli, A. C., Amillis, S., Hall, Z., Lau, A. M., Hanyaloglu, A. C., Diallinas, G., Byrne, B., Politis, A. Dr Argyris Politis: Research Students; Research Outputs Research funding Theses Dr Argyris Politis. #Hansen, K., #Lau, A. M., Giles, K., McDonnell, J. M., Struwe, W. B., Sutton, B. J., Politis, A. Mechanistic insight into the assembly of the HerA-NurA helices-nuclease DNA end resection complex. Despite the realisation that lipids play a critical role for the structure and function of membrane proteins, the complexity of lipid-protein interactions makes them challenging to characterise by conventional tools and they remain poorly described at molecular level. Dr Politis has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. Co-supervised by Dr Jonathan Hopper (OMass Therapeutics). Argyris has 5 jobs listed on their profile. Cardiolipin bound to SecY. The 3rd International Conference on Hydrogen Deuterium Exchange Mass Spectrometry (HDXMS 2021) will be held in London, England, hosted by Dr. Argyris Politis and Dr. David Weis. argyris.politis@kcl.ac.uk. Research Associate in Computational Structural Biology at King's College London, listed on FindAPostDoc.com - A jobs site exclusively listing postdoctoral research posts. A mass-spectrometry-based modelling workflow for accurate prediction of IgG antibody conformations in the gas phase. Politis, A., Stengel, F., Hall, Z., Hernández, H., Leitner, A., Waltzthoeni, T., Robinson, C. V., Aebersold, R. (2014). A mass-spectrometry-based modelling workflow for accurate prediction of IgG antibody conformations in the gas phase. Welcome to the research page of Argyris PolitisThe aim of the Politis lab is to develop novel methods and tools to study the structural dynamics of macromolecular assemblies, important for their cellular function. We combine HDX-MS with native MS and advanced modelling to elucidate the mechanistic interplay between membrane transporters and their surrounding lipid environment. Current work is aiming to understand the role lipids have in structure and function of transporter proteins in collaboration with Dr Argyris Politis, Kings College London and obtain detailed insights into the mechanism of action of G-protein coupled receptor heterodimers in collaboration wtih Dr Aylin Hanyaloglu, Imperial College London. Contact Donna Hutchcraft Fackler. In Brief We describe the first in-depth analysis of membrane lipid interactions with a eukaryotic transporter using native mass spectrometry. Photos from Dr. Argyris Argyriou Paediatrician's post [03/13/20] Αγαπητοί Γονείς, (2018). Joanna is a graduate of Pharmaceutical Analysis and an engineer in Chemical Technology. ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery. We combine HDX-MS with native MS and advanced modelling to elucidate the mechanistic interplay between membrane transporters and their surrounding lipid environment.Our research is funded by the Wellcome Trust, MRC, BBSRC and the Waters Corporation. Research Associate in Computational Structural Biology Chemistry R6/1967/19-BW 019450 Closing date: Midnight on 13 October 2019 The salary will be paid at Grade 6, Spine point 31 £37,689 per annum, inclusive of £3,500 per annum London Allowance. *, Collinson, I. Dr Argyris Politis. • #Hansen, K., #Lau, A. M., Giles, K., McDonnell, J. M., Struwe, W. B., Sutton, B. J., Politis, A. ORCID: 0000-0002-6658-3224. He currently is interested in structural dynamics of macromolecular assemblies by integrated approaches based on mass spectrometry. Dr Argyris Politis . of Chemistry. of Chemistry. His recent work led to the development of a mass spectrometry-based hybrid method for assembly modelling of large and …
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