potassium sparing diuretics ppt
Mechanism. ... • Potassium-sparing diuretic may be used concurrently to prevent or manage hypokalemia. Potassium-Sparing. • Other potassium-sparing diuretics (amiloride or triamte-rene) are generally prescribed for essential hypertension as a fixed-dose combination with hydrochlorothiazide. However, they also increase the amount of potassium passed out of the body through the kidneys. Less powerful than loop diuretics but they retain potassium instead of wasting it. Examples include spironolactone (Aldactone), eplerenone (Inspra) and triamterene (Dyrenium). Potassium Loss Prevention . Background: Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. A subclass of diuretics which does not limit the secretion of POTASSIUM into the URINE. Non Potassium Sparing Diuretics Accession Number DBCAT003863 Description. Potassium-sparing diuretics help to reduce the amount of water in the body by acting on the kidneys to increase the flow of urine. PPT – Diuretics PowerPoint presentation | free to view - id: f4af1-ZDc1Z. As sodium is not reabsorbed potassium is retained within the body resulting in the potassium sparing effect. Other potassium-sparing diuretics may add a few cents to the cost but save a good deal more by the prevention of diuretic-induced hypokalemia and hypomagnesemia. Potassium-sparing diuretics reduce fluid levels in your body without causing you to lose potassium, an important nutrient. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Potassium-Sparing Diuretics As their names suggest, potassium-sparing diuretics work by increasing urine volume without wasting potassium. Actions. Osmotic diuretics: Proximal tubules and descending loop of Henle 2. Chapter Chapter 34 34 Drug Drug Therapy Therapy for for Fluid Fluid Volume Volume Excess Excess Diuretic Use • Increases renal secretion. Potassium-sparing diuretics: Distal Tubule and Collecting duct Carbonic anhydrase inhibitors: Proximal Tubule 3. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe … These medicines can also be used for other conditions as determined by your doctor. Potassium-sparing Diuretics refer to a class of compounds that interfere with sodium resorption within Principal Cells of the late distal tubule and collecting duct (See: Late Distal Tubule and Collecting Duct Transport).Because only a small fraction of urinary sodium is absorbed at this segment, potassium-sparing diuretics are rather weak in terms of their sodium diuresis capacity. Potassium sparing diuretics list Amiloride hydrochloride (Midamar) Amiloride is a potassium-sparing diuretic that does not have much of a diuretic effect when compared to its potassium-sparing activity 1).Amiloride was approved for use in the United States in 1986, but is not widely used. All potassium-sparing diuretics can cause hyperkalemia. However, they do this without causing a loss of potassium, which is … Ion Transport Pathways Across The Luminal And Basolateral Membranes PPT. What do I … Evidence regarding potency, cardiovascular events, sodium, and potassium suggested the hypothesis that “CHIP” diuretics (CHlorthalidone, Indapamide, and Potassium‐sparing diuretic/hydrochlorothiazide [PSD/HCTZ]) would reduce LVM more than HCTZ. Ion transport pathways across the luminal and basolateral membranes of collecting tubule and collecting duct cells. Potassium-sparing diuretics can rid the body of excess sodium. View by Category Toggle navigation. Presentation Summary : Potassium-Sparing Diuretics. • If you need this medicine for another problem, your health care provider will give you more information. Non-postassium sparing diuretics may cause potassium (a mineral in your body) to be lost along with the fluid. Potassium sparing diuretics. Amiloride, triamterene, and the spirolactones are potassium-sparing diuretics which act on the distal parts of the nephron, from the late distal tubule to the collecting duct. Get the plugin now. They competitively bind with aldosterone binding sites but do not activate the binding site as aldosterone would – … The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism. Potassium sparing diuretics prevent excessive loss of potassium at the distal convoluted tubules. Potassium-sparing diuretics refers to drugs that cause diuresis without causing potassium loss in the urine and leading to hyperkalemia. Potassium-sparing diuretics and hydrochlorothiazide may cause your skin to be more sensitive to sunlight than it is normally. diuretics. Presentation Summary : Potassium-Sparing Diuretics. Potassium sparing diuretics e.g. Potassium-sparing like spironolactone or amiloride both act on the collecting tubules but employ different mechanisms of action. Potassium-sparing diuretics encourage the body to get rid of fluids and sodium. diuretic Diuretic dose must be above the natriuretic threshold Causes of diuretic resistance Approach to management of Diuretic resistance DIURETIC COMBINATIONS Loop diuretic and thiazides Syngergistic Loop Diuretics/ Thiazides + Distal Potassium sparing. Drugs. Therapeutic Action. The blood sodium from being reabsorbed into the bloodstream in the distal renal tubule, which means more will be sodium will be excreted in your urine. Potassium-Sparing Diuretics. Ion Transport Pathways Across The Luminal And Basolateral Membranes PPT. Medications called potassium-sparing diuretics don't lower potassium levels. The most commonly used diuretics with a pronounced diuretic effect are thiazides, loop diuretics, and potassium-sparing diuretics. A combination of a potassium sparing diuretic with a thiazide diuretic is used to reduce edema due to salt and water retention in disorders of the heart, kidneys, liver … Diuretics are also sometimes called "water pills". • Potassium sparing diuretics • Calcineurin inhibitors: tacrolimus and cyclosporin Treatment of hyperkalaemia • Stop all drugs • Cardiac stabilization • Redistribute potassium into intracellular fluid • Lower total body potassium Calcium • Critical component of bone and mineralized structures • Intracellular cation World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Typically used for patients who have high risk for hypokalemia associated with diuretic use. Inward diuretics This also helps to lower blood pressure. The risk of torsades-related sudden death should also be reduced. Potassium sparing diuretics are a class of drugs that work by changing way the nephrons in your kidneys produce urine. 1. In these segments, active sodium reabsorption occurs through the following mechanism: sodium ions enter the cell through spe … But, some diuretics and potassium supplements can be harsh on the digestive tract. Not all diuretics cause this problem. Remove this presentation Flag as Inappropriate I Don't Like This I like this Remember as a Favorite. Doctors use various strategies to minimize the potassium loss that occurs as a side effect of using diuretics. Other potassium-sparing diuretics. Pharm lecture PPT: 2/13/ Diuretic Drugs: *increase urine output to lower blood pressure and to draw edema out of the body Anatomy review of kidneys Kidney serves three basic functions: Nephron=functional unit of kidney Cleansing of extracellular fluid (ECF), excretion of metabolic wastes and foreign substances Maintenance of extracellular volume and composition Maintenance of acid … The Adobe Flash plugin is needed to view this content. DIURETIC RESISTANCE Inadequate clearance of edema despite a full dose of. These act at the distal DCT and the cortical collecting ducts. This will help normalize electrolyte levels. spironolactone, eplerenone, amiloride, triamterene. Share Share. Potassium-sparing diuretics are often combined with either a loop diuretic or a thiazide diuretic. Potassium Sparing Diuretics. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. In some cases, your healthcare professional may recommend a special kind of diuretic called potassium-sparing diuretics. View Ch 34 Diuretics.ppt from NURS 6200 at Gordon College. Now we have few of the drugs like amiloride, triamterene, spironolactone and eplerenone that act the collecting tubules and inhibit the sodium reabsorption. Theory, Pharmacology, BDS ADH & Potassium Sparing diuretics BDS - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. This type of diuretics causes a loss of sodium while promoting the retention of potassium. thiazide diuretics) and much less commonly prescribed as monotherapy. Ion transport pathways across the luminal and basolateral membranes of collecting tubule and collecting duct cells. Osmotic diuretics and carbonic anhydrase inhibitors are used in acute settings to lower intracranial and/or intraocular pressure … Potassium Sparing Diuretics. They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. Hyperkalemia. Inward The optimal thiazide‐type diuretic for reducing LVM is unknown. Loop diuretics: Ascending loop of Henle 4. Diuretics: Potassium-sparing diuretics: – Act on the distal portion of the distal tube (where Na+ is exchanged for K+) – Aldosterone promotes reabsorption of Na + in exchange for K (transcriptionally upregulates the Na+/K+ pump and sodium channels) • Spironolactone – Aldosterone receptor antagonist – Onset of action requires several days Potassium sparing diuretics are usually pretty weak, so they are used in combination with other diuretics, like loop or thiazides that would normally cause renal potassium wasting and hypokalemia. Thiazide and thiazide-like diuretics: Distal tubule 5. Loop diuretics and thiazide diuretics are stronger than potassium-sparing diuretics with regard to making the kidneys pass out more fluid.