The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is highly expressed in liver, kidney, adrenals, and intestine. The farnesoid X receptor (FXR) is the nuclear hormone receptor that binds bile acids and regulates transcription of multiple genes that are key to many aspects of metabolism, especially those involving bile acids themselves. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. Mutational analysis of these sites and experiments in transgenic mice lacking FXR or PXR support the relevance of FXR activation for CYP3A regulation. Ex-pression by transfection of FXR … At FXR Factory Racing Inc racing is the ultimate test of man and machine, pushing the limits of your equipment to its boundaries, pushing your body both mentally and physically past its limits. FXR was previously proposed to play an important role in the pathogenesis of cardiovascular diseases via regulating the metabolism and transport of cholesterol. Regarding liver-restricted nuclear receptors, we previously identi-fied 2 response elements for the farnesoid X receptor (FXR) a (nuclear bile acid receptor) located within the enhancer II/core promoter region (EnhII/Cp) (12). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. Receptor proteins can be classified by their location. Transmembrane receptors include ion channel-linked (ionotropic) receptors, G protein-linked (metabotropic) hormone receptors, and enzyme-linked hormone receptors. The Farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily that has been shown to play an important role in bile acid and cholesterol homeostasis. We tested prototypical ligands for the nuclear receptors pregnane X receptor (PXR), constitutive androstane receptor (CAR), liver X receptor (LXR) α, and farnesoid X receptor (FXR) in a human hepatoma‐derived cell line and noted induction of OATP1B1 mRNA when the cells were treated with LXRα or FXR ligands. Farnesoid X receptor (FXR, encoded by NR1H4), a critical regulator of bile acid homeostasis, is widely implicated in human tumorigenesis. As a ligand-activated transcription factor, FXR regulates expression of target genes involved in enterohepatic circulation and lipid homeostasis ( 5 ). As non-BAs drug template for GPBAR1, none of the natural oleanane-type triterpenes have been reported as FXR ligands, despite FXR and GPBAR1 having similar binding pockets for BAs. Testing yourself against fellow competitors, pushing the limitsof what you believe is possible to achieve. This review describes the involvement of FXR in the condition known as bile acid diarrhea (BAD). Our data provide evidence for the presence of two functional FXR recognition sites located in a 345-bp element within the 5'-flanking region of CYP3A4. Here we identify four murine FXR transcripts, derived from a single gene, that encode four isoforms, FXRα1, FXRα2, FXRβ1, and FXRβ2. located in these cis-regulating regions (11). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is expressed in various tissues including liver, intestine, kidneys, and adrenal gland . Farnesoid X receptor (FXR) and G-protein-coupled bile acid receptor 1 (GPBAR1) are two important bile acid (BA) receptors.